Versatile human cardiac tissues engineered with perfusable heart extracellular microenvironment for biomedical applications.

ABSTRACT: Engineered human cardiac tissues have been utilized for various biomedical applications, including drug testing, disease modeling, and regenerative medicine. However, the applications of cardiac tissues derived from human pluripotent stem cells are often limited due to their immaturity and lack of functionality. Therefore, in this study, we establish a perfusable culture system based on in vivo-like heart microenvironments to improve human cardiac tissue fabrication. The integrated culture platform of a microfluidic chip and a three-dimensional heart extracellular matrix enhances human cardiac tissue development and their structural and functional maturation. These tissues are comprised of cardiovascular lineage cells, including cardiomyocytes and cardiac fibroblasts derived from human ind

SUBMITTER: Min S 

PROVIDER: S-EPMC10960018 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature