Mitochondrial sirtuins: Energy dynamics and cancer metabolism.
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ABSTRACT:
SUBMITTER: Lee H
PROVIDER: S-EPMC10960136 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Publications
Mitochondrial sirtuins: Energy dynamics and cancer metabolism.
Molecules and cells 20240206 2
Mitochondria are pivotal for energy regulation and are linked to cancer. Mitochondrial sirtuins, (Sirtuin) SIRT3, SIRT4, and SIRT5, play crucial roles in cancer metabolism. This review explores their impact on cellular processes, with a focus on the NAD+ interplay and the modulation of their enzymatic activities. The varied roles of SIRT3, SIRT4, and SIRT5 in metabolic adaptation and cancer are outlined, emphasizing their tumor suppressor or oncogenic nature. We propose new insights into sirtuin ...[more]
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