Unknown

Dataset Information

0

Transcriptomics analysis of LINC02202/XBP1 axis in melanoma: Implications for drug targeting and PD-1 monoclonal antibody efficacy.


ABSTRACT: Malignant melanoma (MM) is a highly aggressive and deadly form of skin cancer, primarily caused by recurrence and metastasis. Therefore, it is crucial to investigate the regulatory mechanisms underlying melanoma recurrence and metastasis. Our study has identified a potential targeted regulatory relationship between LINC02202, miR-526b-3p and XBP1 in malignant melanoma. Through the regulation of the miR-526b-3p/XBP1 signalling pathway, LINC02202 may play a role in tumour progression and immune infiltration and inhibiting the expression of LINC02202 can increase the efficacy of immunotherapy for melanoma. Our findings shed light on the impact of LINC02202/XBP1 on the phenotype and function of malignant melanoma cells. Furthermore, this study provides a theoretical foundation for the development of novel immunotherapy strategies for malignant melanoma.

SUBMITTER: Shang Y 

PROVIDER: S-EPMC10960173 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature

altmetric image

Publications

Transcriptomics analysis of LINC02202/XBP1 axis in melanoma: Implications for drug targeting and PD-1 monoclonal antibody efficacy.

Shang Yuanyuan Y   Yang Haiqian H   Cui Jian J   Wang Lipeng L   Wang Le L   Wang Yuan Y   Zhao Miao-Miao MM   Yu Pei-Yao PY   Qiao Hui H   Yang Wen-Jun WJ  

Journal of cellular and molecular medicine 20240401 8


Malignant melanoma (MM) is a highly aggressive and deadly form of skin cancer, primarily caused by recurrence and metastasis. Therefore, it is crucial to investigate the regulatory mechanisms underlying melanoma recurrence and metastasis. Our study has identified a potential targeted regulatory relationship between LINC02202, miR-526b-3p and XBP1 in malignant melanoma. Through the regulation of the miR-526b-3p/XBP1 signalling pathway, LINC02202 may play a role in tumour progression and immune in  ...[more]

Similar Datasets

| S-EPMC5567082 | biostudies-literature
| S-EPMC4741437 | biostudies-literature
| S-EPMC5665071 | biostudies-literature
| S-EPMC5749922 | biostudies-literature
| S-EPMC5800393 | biostudies-literature
| S-EPMC8671946 | biostudies-literature
| S-EPMC3490105 | biostudies-literature
| S-EPMC5364262 | biostudies-literature
| S-EPMC5777972 | biostudies-literature
2021-10-20 | GSE183545 | GEO