Glucagon-like peptide 1 receptor activation: anti-inflammatory effects in the brain.

ABSTRACT: The glucagon-like peptide 1 is a pleiotropic hormone that has potent insulinotropic effects and is key in treating metabolic diseases such as diabetes and obesity. Glucagon-like peptide 1 exerts its effects by activating a membrane receptor identified in many tissues, including different brain regions. Glucagon-like peptide 1 activates several signaling pathways related to neuroprotection, like the support of cell growth/survival, enhancement promotion of synapse formation, autophagy, and inhibition of the secretion of proinflammatory cytokines, microglial activation, and apoptosis during neural morphogenesis. The glial cells, including astrocytes and microglia, maintain metabolic homeostasis and defense against pathogens in the central nervous system. After brain insult, microglia are the

SUBMITTER: Diz-Chaves Y 

PROVIDER: S-EPMC10960307 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature