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Targeted protein degradation in hematologic malignancies: latest updates from the 2023 ASH annual meeting.

ABSTRACT: Protein degraders, emerging as a novel class of therapeutic agents, have gained widespread attention due to their advantages. They have several advantages over traditional small molecule inhibitors, including high target selectivity and ability to target "undruggable" targets and overcome inhibitor drug resistance. Tremendous research and development efforts and massive investment have resulted in rapid advancement of protein degrader drug discovery in recent years. Here, we overview the latest clinical and preclinical updates on protein degraders presented at the 2023 ASH Annual Meeting.

SUBMITTER: Zhong G

PROVIDER: S-EPMC10960432 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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Targeted protein degradation in hematologic malignancies: latest updates from the 2023 ASH annual meeting.

Zhong Guangcai G Kong Ran R Feng Shi S Wang Cong C Hao Qingbo Q Xie Weilin W Zhou Xiangxiang X

Journal of hematology & oncology 20240322 1

Protein degraders, emerging as a novel class of therapeutic agents, have gained widespread attention due to their advantages. They have several advantages over traditional small molecule inhibitors, including high target selectivity and ability to target "undruggable" targets and overcome inhibitor drug resistance. Tremendous research and development efforts and massive investment have resulted in rapid advancement of protein degrader drug discovery in recent years. Here, we overview the latest ...[more]

PMID: 38520028

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