Tumor-derived miR-6794-5p enhances cancer growth by promoting M2 macrophage polarization.

ABSTRACT:

Background

Solid tumors promote tumor malignancy through interaction with the tumor microenvironment, resulting in difficulties in tumor treatment. Therefore, it is necessary to understand the communication between cells in the tumor and the surrounding microenvironment. Our previous study revealed the cancer malignancy mechanism of Bcl-w overexpressed in solid tumors, but no study was conducted on its relationship with immune cells in the tumor microenvironment. In this study, we sought to discover key factors in exosomes secreted from tumors overexpressing Bcl-w and analyze the interaction with the surrounding tumor microenvironment to identify the causes of tumor malignancy.

Methods

To analyze factors affecting the tumor microenvironment, a miRNA array was performed using

SUBMITTER: Choi JY 

PROVIDER: S-EPMC10960442 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature