Dataset Information

Association Between Urinary Biomarkers and CKD in Extremely Low Gestational Age Neonates.

ABSTRACT:

Rationale & objective

Children born before 28 weeks' gestation are at increased risk of chronic kidney disease (CKD). Urine biomarkers may shed light on mechanistic pathways and improve the ability to forecast CKD. We evaluated whether urinary biomarkers in neonates of low gestational age (GA) are associated with a reduced estimated glomerular filtration rate (eGFR) over time.

Study design

A cohort study of neonates with an exploratory case-control study of a subset of the cohort.

Setting & participants

327 neonates born at 24-27 weeks' gestation with 2-year eGFR data from the PENUT (Preterm Erythropoietin Neuroprotection Trial) and the REPaIReD (Recombinant Erythropoietin for Prevention of Infant Renal Disease) study.