Increased di-(2-ethylhexyl) phthalate exposure poses a differential risk for adult asthma clusters.

ABSTRACT:

Background

DEHP, a common plasticizer known for its hormone-disrupting properties, has been associated with asthma. However, a significant proportion of adult asthma cases are "non-atopic", lacking a clear etiology.

Methods

In a case-control study conducted between 2011 and 2015, 365 individuals with current asthma and 235 healthy controls from Kaohsiung City were enrolled. The control group comprised individuals without asthma, Type 2 Diabetes Mellitus (T2DM), hypertension, or other respiratory/allergic conditions. The study leveraged asthma clusters (Clusters A to F) established in a prior investigation. Analysis involved the examination of urinary DEHP metabolites (MEHP and MEHHP), along with the assessment of oxidative stress, sphingolipid metabolites, and inflammatory b

SUBMITTER: Hsu YT 

PROVIDER: S-EPMC10960985 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature