Transcription factor expression landscape in Drosophila embryonic cell lines.

ABSTRACT:

Background

Transcription factor (TF) proteins are a key component of the gene regulatory networks that control cellular fates and function. TFs bind DNA regulatory elements in a sequence-specific manner and modulate target gene expression through combinatorial interactions with each other, cofactors, and chromatin-modifying proteins. Large-scale studies over the last two decades have helped shed light on the complex network of TFs that regulate development in Drosophila melanogaster.

Results

Here, we present a detailed characterization of expression of all known and predicted Drosophila TFs in two well-established embryonic cell lines, Kc167 and S2 cells. Using deep coverage RNA sequencing approaches we investigate the transcriptional profile of all 707 TF coding genes in bo

SUBMITTER: Drewell RA 

PROVIDER: S-EPMC10960990 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature