B-cell intrinsic regulation of antibody mediated immunity by histone H2A deubiquitinase BAP1.

ABSTRACT:

Introduction

BAP1 is a deubiquitinase (DUB) of the Ubiquitin C-terminal Hydrolase (UCH) family that regulates gene expression and other cellular processes, through its direct catalytic activity on the repressive epigenetic mark histone H2AK119ub, as well as on several other substrates. BAP1 is also a highly important tumor suppressor, expressed and functional across many cell types and tissues. In recent work, we demonstrated a cell intrinsic role of BAP1 in the B cell lineage development in murine bone marrow, however the role of BAP1 in the regulation of B cell mediated humoral immune response has not been previously explored.

Methods and results

In the current study, we demonstrate that a B-cell intrinsic loss of BAP1 in activated B cells in the Bap1 ^fl/fl

SUBMITTER: Liang Y 

PROVIDER: S-EPMC10961346 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature