A lactate metabolism-related signature predicting patient prognosis and immune microenvironment in ovarian cancer.

ABSTRACT:

Introduction

Ovarian cancer (OV) is a highly lethal gynecological malignancy with a poor prognosis. Lactate metabolism is crucial for tumor cell survival, proliferation, and immune evasion. Our study aims to investigate the role of lactate metabolism-related genes (LMRGs) in OV and their potential as biomarkers for prognosis, immune microenvironment, and immunotherapy response.

Methods

Ovarian samples were collected from the TCGA cohort. And 12 lactate-related pathways were identified from the MsigDB database. Differentially expressed genes within these pathways were designated as LMRGs, which undergo unsupervised clustering to identify distinct clusters based on LMRGs. Subsequently, we assessed survival outcomes, immune cell infiltration levels, Hallmaker pathway activation

SUBMITTER: Zhu L 

PROVIDER: S-EPMC10961354 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature