Antibody-mediated depletion of select leukocyte subsets in blood and tissue of nonhuman primates.

ABSTRACT: Understanding the immunological control of pathogens requires a detailed evaluation of the mechanistic contributions of individual cell types within the immune system. While knockout mouse models that lack certain cell types have been used to help define the role of those cells, the biological and physiological characteristics of mice do not necessarily recapitulate that of a human. To overcome some of these differences, studies often look towards nonhuman primates (NHPs) due to their close phylogenetic relationship to humans. To evaluate the immunological role of select cell types, the NHP model provides distinct advantages since NHP more closely mirror the disease manifestations and immunological characteristics of humans. However, many of the experimental manipulations routinely used in

SUBMITTER: Sutton MS 

PROVIDER: S-EPMC10961357 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature