Comparative immunohistochemical analysis of inflammatory cytokines in distinct subtypes of Sweet syndrome.

ABSTRACT:

Background

A dysregulated immune response has been implicated in Sweet syndrome (SS) pathogenesis; however, cytokine profiles across different conditions associated with SS - including adult-onset immunodeficiency (AOID) due to anti-interferon (IFN)-γ autoantibodies - remain unknown.

Objective

To investigate alterations in inflammatory cytokines in skin lesions of distinct subtypes of SS.

Methods

Skin biopsies were collected from 42 AOID- and 52 non-AOID-associated SS patients and 18 healthy controls. The comparative immunohistochemical study was conducted using monoclonal antibodies against interleukin (IL)-1β, IL-6, IL-17, IFN-γ, and tumor necrosis factor-α on paraffin-embedded sections. The quantitative percentage positivity and intensity were calculated using comp

SUBMITTER: Chieosilapatham P 

PROVIDER: S-EPMC10961367 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature