Vaccination with staphylococcal protein A protects mice against systemic complications of skin infection recurrences.

ABSTRACT: Skin and soft tissue infections (SSTIs) are the most common diseases caused by Staphylococcus aureus (S. aureus), which can progress to threatening conditions due to recurrences and systemic complications. Staphylococcal protein A (SpA) is an immunomodulator antigen of S. aureus, which allows bacterial evasion from the immune system by interfering with different types of immune responses to pathogen antigens. Immunization with SpA could potentially unmask the pathogen to the immune system, leading to the production of antibodies that can protect from a second encounter with S. aureus, as it occurs in skin infection recurrences. Here, we describe a study in which mice are immunized with a mutated form of SpA mixed with the Adjuvant System 01 (SpA_mut/AS

SUBMITTER: Mandelli AP 

PROVIDER: S-EPMC10961379 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature