Metabolic profiling of synovial fluid in human temporomandibular joint osteoarthritis.

ABSTRACT:

Introduction

Temporomandibular joint (TMJ) osteoarthritis (OA) is a common TMJ degenerative disease with an unclear mechanism. Synovial fluid (SF), an important component of TMJ, contains various proteins and metabolites that may directly contribute to OA. The present study aimed to investigate the influence of SF in TMJOA at the metabolite level.

Methods

Untargeted and widely targeted metabolic profiling were employed to identify metabolic changes in SF of 90 patients with different TMJOA grades according to TMJ magnetic resonance imaging.

Results

A total 1498 metabolites were detected. Most of the metabolites were amino acids and associated metabolites, benzene and substituted derivatives, and lipids. Among patients with mild, moderate and severe TMJOA, 164 graduall

SUBMITTER: Zhang D 

PROVIDER: S-EPMC10961395 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature