A computational study of right ventricular mechanics in a rat model of pulmonary arterial hypertension.

ABSTRACT: Pulmonary arterial hypertension (PAH) presents a significant challenge to right ventricular (RV) function due to progressive pressure overload, necessitating adaptive remodeling in the form of increased wall thickness, enhanced myocardial contractility and stiffness to maintain cardiac performance. However, the impact of these remodeling mechanisms on RV mechanics in not clearly understood. In addition, there is a lack of quantitative understanding of how each mechanism individually influences RV mechanics. Utilizing experimental data from a rat model of PAH at three distinct time points, we developed biventricular finite element models to investigate how RV stress and strain evolved with PAH progression. The finite element models were fitted to hemodynamic and morphological data to repres

SUBMITTER: Odeigah OO 

PROVIDER: S-EPMC10961401 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature