Independent association of general and central adiposity with risk of gallstone disease: observational and genetic analyses.

ABSTRACT:

Background

General obesity is a well-established risk factor for gallstone disease (GSD), but whether central obesity contributes additional independent risk remains controversial. We aimed to comprehensively clarify the effect of body fat distribution on GSD.

Methods

We first investigated the observational association of central adiposity, characterized by waist-to-hip ratio (WHR), with GSD risk using data from UK Biobank (N=472,050). We then explored the genetic relationship using summary statistics from the largest genome-wide association study of GSD (n_case=43,639, n_control=506,798) as well as WHR, with and without adjusting for body mass index (BMI) (WHR: n=697,734; WHR_adjBMI: n=694,649).

Results

Observ

SUBMITTER: Zhang M 

PROVIDER: S-EPMC10961427 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature