Population genomic evidence of structured and connected Plasmodium vivax populations under host selection in Latin America.

ABSTRACT: Pathogen genomic epidemiology has the potential to provide a deep understanding of population dynamics, facilitating strategic planning of interventions, monitoring their impact, and enabling timely responses, and thereby supporting control and elimination efforts of parasitic tropical diseases. Plasmodium vivax, responsible for most malaria cases outside Africa, shows high genetic diversity at the population level, driven by factors like sub-patent infections, a hidden reservoir of hypnozoites, and early transmission to mosquitoes. While Latin America has made significant progress in controlling Plasmodium falciparum, it faces challenges with residual P. vivax. To characterize genetic diversity and population structure and dynamics, we have analyzed the largest collec

SUBMITTER: Kattenberg JH 

PROVIDER: S-EPMC10961478 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature