Advances and challenges in cancer immunoprevention and immune interception.

ABSTRACT: Invasive cancers typically evade immune surveillance through profound local and systemic immunosuppression, preventing their elimination or control. Targeting immune interventions to prevent or intercept premalignant lesions, before significant immune dysregulation has occurred, may be a more successful strategy. The field of cancer immune interception and prevention is nascent, and the scientific community has been slow to embrace this potentially most rational approach to reducing the global burden of cancer. This may change due to recent promising advances in cancer immunoprevention including the use of vaccines for the prevention of viral cancers, the use of cancer-associated antigen vaccines in the setting of precancers, and the development of cancer-preventative vaccines for high-ris

SUBMITTER: Stanton SE 

PROVIDER: S-EPMC10961508 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature