Prepregnancy body mass index and other risk factors for early-onset and late-onset haemolysis, elevated liver enzymes and low platelets (HELLP) syndrome: a population-based retrospective cohort study in British Columbia, Canada.

ABSTRACT:

Background

Obesity increases risk of pre-eclampsia, but the association with haemolysis, elevated liver enzymes and low platelets (HELLP) syndrome is understudied.

Objective

To examine the association between prepregnancy body mass index (BMI) and HELLP syndrome, including early-onset versus late-onset disease.

Study design

A retrospective cohort study using population-based data.

Setting

British Columbia, Canada, 2008/2009-2019/2020.

Population

All pregnancies resulting in live births or stillbirths at ≥20 weeks' gestation.

Methods

BMI categories (kg/m²) included underweight (<18.5), normal (18.5-24.9), overweight (25.0-29.9) and obese (≥30.0). Rates of early-onset and late-onset HELLP syndrome (<34 vs ≥34 weeks, respectively) were cal

SUBMITTER: Wang LQ 

PROVIDER: S-EPMC10961512 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature