Effects of paternal ionizing radiation exposure on fertility and offspring's health.

ABSTRACT:

Purpose

The intergenerational effects of ionizing radiation remain controversial. Extensive insights have been revealed for DNA mutations and cancer incidence in progeny, yet many of these results were obtained by immediate post-radiation mating. However, conception at short times after radiation exposure is likely to be avoided. After a long period of fertility recovery, whether unexposed sperm derived from exposed spermatogonia would challenge the health of the offspring is not yet clearly demonstrated.

Methods

Ten-week-old C57BL/6J males underwent whole-body acute γ irradiation at 0 and 6.4 Gy. Testes and sperm were collected at different times after radiation to examine reproductive changes. The reproductive, metabolic, and neurodevelopmental parameters were measured in

SUBMITTER: Li J 

PROVIDER: S-EPMC10961711 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature