Diagnostic value of serum COMP and ADAMTS7 for intervertebral disc degeneration.

ABSTRACT:

Objective

Intervertebral disc degeneration (IVDD) is a major cause of morbidity and disability. Our study aimed to investigate the potential of cartilage oligomeric matrix protein (COMP) and ADAMTS7 (A disintegrin and metalloproteinases with thrombospondin motifs 7) as biomarkers for IVDD together with their functional relationship.

Methods

IVD tissues and peripheral blood samples were collected from IVDD rabbit models over 1-4 weeks. Tissues and blood samples were also collected from clinical patients those were stratified into four equal groups according to Pfirrmann IVDD grading (I-V) with baseline data collected for each participant. COMP and ADAMTS7 expression were analyzed and biomarker characteristics were assessed using linear regression and receiver operating curve

SUBMITTER: Ding JY 

PROVIDER: S-EPMC10962093 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature