Periodontitis and Sjogren's syndrome: a bidirectional two-sample mendelian randomization study.

ABSTRACT:

Objectives

Observational studies indicated a controversial relationship between periodontitis (PD) and Sjogren's syndrome (SS). To overcome restrictions in conventional observational studies, we conducted a two-sample Mendelian randomization (MR) analysis to assess the potential bidirectional relationship between PD and SS.

Methods

We utilized the largest available genome-wide association study (GWAS) of European ancestry on both PD (17,353 cases-28,210 controls) and SS (2495 cases-365,533 controls) for MR genetic instrument selection. The random-effect inverse-variance weighted (IVW) method complemented by Causal Analysis Using Summary Effect (CAUSE), weighted median, weighted mode, simple mode, MR-Egger regression, and MR-pleiotropy residual sum and outlier (MR-PRESSO) was

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10962100 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature