Childhood maltreatment and health in the UK Biobank: triangulation of outcome-wide and polygenic risk score analyses.

ABSTRACT:

Background

Childhood maltreatment is common globally and impacts morbidity, mortality, and well-being. Our understanding of its impact is constrained by key substantive and methodological limitations of extant research, including understudied physical health outcomes and bias due to unmeasured confounding. We address these limitations through a large-scale outcome-wide triangulation study.

Methods

We performed two outcome-wide analyses (OWAs) in the UK Biobank. First, we examined the relationship between self-reported maltreatment exposure (number of maltreatment types, via Childhood Trauma Screener) and 414 outcomes in a sub-sample of 157,316 individuals using generalized linear models ("observational OWA"). Outcomes covered a broad range of health themes including health b

SUBMITTER: Espinosa Dice AL 

PROVIDER: S-EPMC10962116 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature