Extracorporeal photopheresis reduces inflammation and joint damage in a rheumatoid arthritis murine model.

ABSTRACT:

Background

Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammatory reactions and tissue damage in the joints. Long-term drug use in clinical practice is often accompanied by adverse reactions. Extracorporeal photopheresis (ECP) is an immunomodulatory therapy with few side effects, offering a potential and safe therapeutic alternative for RA through the induction of immune tolerance. This study aimed to investigate the therapeutic effects of ECP on RA using a collagen-induced arthritis (CIA) murine model, as well as to explore its immunomodulatory effects in vivo. Additionally, particular attention was given to the significant role of monocytes during the ECP process.

Methods

A murine model of rheumatoid arthritis was established by administering two

SUBMITTER: Lin Y 

PROVIDER: S-EPMC10962138 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature