Decision-making and autonomy among participants in early-phase cancer immunotherapy trials: a qualitative study.

ABSTRACT:

Background

Participants considering early-phase cancer clinical trials (CTs) need to understand the unique risks and benefits prior to providing informed consent. This qualitative study explored the factors that influence patients' decisions about participating in early-phase cancer immunotherapy CTs through the ethical lens of relational autonomy.

Methods

Using an interpretive descriptive design, interviews were conducted with 21 adult patients with advanced cancer who had enrolled in an early-phase CT. Data was analyzed using relational autonomy ethical theory and constant comparative analysis.

Results

The extent to which participants perceived themselves as having a choice to participate in early-phase cancer immunotherapy CTs was a central construct. Perceptions o

SUBMITTER: Avery J 

PROVIDER: S-EPMC10962144 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature