Large-scale next generation sequencing based analysis of SLCO1B1 pharmacogenetics variants in the Saudi population.

ABSTRACT:

Background

SLCO1B1 plays an important role in mediating hepatic clearance of many different drugs including statins, angiotensin-converting enzyme inhibitors, chemotherapeutic agents and antibiotics. Several variants in SLCO1B1 have been shown to have a clinically significant impact, in relation to efficacy of these medications. This study provides a comprehensive overview of SLCO1B1 variation in Saudi individuals, one of the largest Arab populations in the Middle East.

Methods

The dataset of 11,889 (9,961 exomes and 1,928 pharmacogenetic gene panel) Saudi nationals, was used to determine the presence and frequencies of SLCO1B1 variants, as described by the Clinical Pharmacogenetic Implementation Consortium (CPIC).

Results

We identified 141 previously described SNPs,

SUBMITTER: Goljan E 

PROVIDER: S-EPMC10962151 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature