Association of distance to swine concentrated animal feeding operations with immune-mediated diseases: An exploratory gene-environment study.

ABSTRACT:

Background

Concentrated animal feeding operations (CAFOs) are a source of environmental pollution and have been associated with a variety of health outcomes. Immune-mediated diseases (IMD) are characterized by dysregulation of the normal immune response and, while they may be affected by gene and environmental factors, their association with living in proximity to a CAFO is unknown.

Objectives

We explored gene, environment, and gene-environment (GxE) relationships between IMD, CAFOs, and single nucleotide polymorphisms (SNPs) of prototypical xenobiotic response genes AHR, ARNT, and AHRR and prototypical immune response gene PTPN22.

Methods

The exposure analysis cohort consisted of 6,464 participants who completed the Personalized Environment and Genes Study Health and

SUBMITTER: Ayala-Ramirez M 

PROVIDER: S-EPMC10962257 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature