Oral and gut microbial profiling in periodontitis and Parkinson's disease.

ABSTRACT:

Objectives

We tested the hypothesis that Parkinson's disease (PA) alters the periodontitis-associated oral microbiome.

Method

Patients with periodontitis with Parkinson's disease (PA+P) and without PA (P) and systemically and periodontally healthy individuals (HC) were enrolled. Clinical, periodontal and neurological parameters were recorded. The severity of PA motor functions was measured. Unstimulated saliva samples and stool samples were collected. Next-generation sequencing of 16S ribosomal RNA (V1-V3 regions) was performed.

Results

PA patients had mild-to-moderate motor dysfunction and comparable plaque scores as those without, indicating that oral hygiene was efficient in the PA+P group. In saliva, there were statistically significant differences in beta diversi

SUBMITTER: Yay E 

PROVIDER: S-EPMC10962298 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature