Synthetic and Computational Design Insights toward Mimicking Protein Binding of Phosphate.

ABSTRACT: The unique and precise capabilities of proteins are renowned for their specificity and range of application. Effective mimicking of protein-binding offers enticing potential to direct their abilities toward useful applications, but it is nevertheless quite difficult to realize this characteristic of protein behavior in a synthetic material. Here, we design, synthesize, and evaluate experimentally and computationally a series of multicomponent phosphate-binding peptide amphiphile micelles to derive design insights into how protein binding behavior translates to synthetic materials. By inserting the Walker A P-loop binding motif into this peptide synthetic material, we successfully implemented the protein-binding design parameters of hydrogen-bonding and electrostatic interaction to bind pho

SUBMITTER: Fowler WC 

PROVIDER: S-EPMC10962344 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature