Disease-modifying therapy in progressive multiple sclerosis: a systematic review and network meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Currently, disease-modifying therapies (DMTs) for progressive multiple sclerosis (PMS) are widely used in clinical practice. At the same time, there are a variety of drug options for DMTs, but the effect of the drugs that can better relieve symptoms and improve the prognosis are still inconclusive.

Objectives

This systematic review aimed to evaluate the efficacy and safety of DMTs for PMS and to identify the best among these drugs.

Methods

MEDLINE, EMBASE, the Cochrane Library, and clinicaltrials.gov were systematically searched to identify relevant studies published before 30 January, 2023. We assessed the certainty of the evidence using the confidence in the network meta-analysis (CINeMA) framework. We estimated the summary risk ratio (RR) for dichotomous

SUBMITTER: Wu X 

PROVIDER: S-EPMC10962394 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature