Relationship of Perivascular Space Markers With Incident Dementia in Cerebral Small Vessel Disease.

ABSTRACT:

Background

Recent studies, using diffusion tensor image analysis along the perivascular space (DTI-ALPS), suggest impaired perivascular space (PVS) function in cerebral small vessel disease, but they were cross-sectional, making inferences on causality difficult. We determined associations between impaired PVS, measured using DTI-ALPS and PVS volume, and cognition and incident dementia.

Methods

In patients with lacunar stroke and confluent white matter hyperintensities, without dementia at baseline, recruited prospectively in a single center, magnetic resonance imaging was performed annually for 3 years, and cognitive assessments, including global, memory, executive function, and processing speed, were performed annually for 5 years. We determined associations between DTI-AL

SUBMITTER: Hong H 

PROVIDER: S-EPMC10962441 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature