Paramagnetic Relaxation Agents for Enhancing Temporal Resolution and Sensitivity in Multinuclear FlowNMR Spectroscopy.

ABSTRACT: Sensitivity in FlowNMR spectroscopy for reaction monitoring often suffers from low levels of pre-magnetisation due to limited residence times of the sample in the magnetic field. While this in-flow effect is tolerable for high sensitivity nuclei such as ¹ H and ¹⁹ F, it significantly reduces the signal-to-noise ratio in ³¹ P and ¹³ C spectra, making FlowNMR impractical for low sensititvity nuclei at low concentrations. Paramagnetic relaxation agents (PRAs), which enhance polarisation and spin-lattice relaxation, could eliminate the adverse in-flow effect and improve the signal-to-noise ratio. Herein, [Co(acac)₃ ], [Mn(acac)₃ ], [Fe(acac)₃ ]_, [Cr(acac)₃ ]_, [Ni(acac)₂ ]

SUBMITTER: Bara-Estaun A 

PROVIDER: S-EPMC10962566 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature