Assessing within-subject rates of change of placental MRI diffusion metrics in normal pregnancy.

ABSTRACT:

Purpose

Studying placental development informs when development is abnormal. Most placental MRI studies are cross-sectional and do not study the extent of individual variability throughout pregnancy. We aimed to explore how diffusion MRI measures of placental function and microstructure vary in individual healthy pregnancies throughout gestation.

Methods

Seventy-nine pregnant, low-risk participants (17 scanned twice and 62 scanned once) were included. T₂ -weighted anatomical imaging and a combined multi-echo spin-echo diffusion-weighted sequence were acquired at 3 T. Combined diffusion-relaxometry models were performed using both a T2*$$ {\mathrm{T}}_2^{\ast } $$ -ADC and a bicompartmental T2*$$ {\mathrm{T}}_2^{\ast } $$ -intravoxel-incoherent-motion ( T2*IVIM$$ {

SUBMITTER: Cromb D 

PROVIDER: S-EPMC10962570 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature