Measuring cardiomyocyte cellular characteristics in cardiac hypertrophy using diffusion-weighted MRI.

ABSTRACT:

Purpose

This paper presents a hierarchical modeling approach for estimating cardiomyocyte major and minor diameters and intracellular volume fraction (ICV) using diffusion-weighted MRI (DWI) data in ex vivo mouse hearts.

Methods

DWI data were acquired on two healthy controls and two hearts 3 weeks post transverse aortic constriction (TAC) using a bespoke diffusion scheme with multiple diffusion times ( Δ$$ \Delta $$ ), q-shells and diffusion encoding directions. Firstly, a bi-exponential tensor model was fitted separately at each diffusion time to disentangle the dependence on diffusion times from diffusion weightings, that is, b-values. The slow-diffusing component was attributed to the restricted diffusion inside cardiomyocytes. ICV was then extrapolated at Δ=0$$ \Delta =0

SUBMITTER: Farzi M 

PROVIDER: S-EPMC10962572 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature