Iron depletion has different consequences on the growth and survival of Toxoplasma gondii strains.

ABSTRACT: Toxoplasma gondii is an obligate intracellular parasite responsible for a pathology called toxoplasmosis, which primarily affects immunocompromised individuals and developing foetuses. The parasite can scavenge essential nutrients from its host to support its growth and survival. Among them, iron is one of the most important elements needed to sustain basic cellular functions as it is involved in a number of key metabolic processes, including oxygen transport, redox balance, and electron transport. We evaluated the effects of an iron chelator on the development of several parasite strains and found that they differed in their ability to tolerate iron depletion. The growth of parasites usually associated with a model of acute toxoplasmosis was strongly affected by iron depletion, whe

SUBMITTER: Renaud EA 

PROVIDER: S-EPMC10962585 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature