Maternal restricted- and over- feeding during gestation perturb offspring sperm epigenome in sheep.

ABSTRACT:

In brief

Inadequate maternal nutrition during gestation can have immediate and lifelong effects on offspring. This study shows that maternal restricted - and over- nutrition during gestation do not affect semen characteristics in F1 male offspring but alters offspring sperm sncRNA profiles and DNA methylome in sheep.

Abstract

There is a growing body of evidence that inadequate maternal nutrition during gestation can have immediate and lifelong effects on offspring. However, little is known about the effects of maternal nutrition during gestation on male offspring reproduction. Here, using a sheep model of maternal restricted - and over - nutrition (60 or 140% of the National Research Council requirements) during gestation, we found that maternal restricted - and over - nutri

SUBMITTER: Zhu L 

PROVIDER: S-EPMC10962644 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature