Inhibitory Effect of P22077 on Airway Inflammation in Rats with COPD and Its Mechanism.

ABSTRACT:

Purpose

Here, we studied the pharmacological effect of P22077 on airway inflammation induced by lipopolysaccharide and cigarette smoke and explored the therapeutic mechanism of P22077 in COPD model RAT.

Patients and methods

The COPD model was established by lipopolysaccharide combined with fumigation; animals were treated with vehicle or P22077. Serum, bronchoalveolar lavage fluid (BALF), and lung tissues were collected for analysis.

Results

Our results showed that P22077 treatment significantly improved the airway inflammation of COPD model RAT and reduced the recruitment of leukocytes in BALF, and hypersecretion of interleukin-18 (IL-18), interleukin-1β (IL-1β) in BALF and serum. H&E staining showed that P22077 treatment could effectively reduce emphysema, immune ce

SUBMITTER: Zeng D 

PROVIDER: S-EPMC10962660 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature