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Isolation of GLP-1 enhancing indolizidine alkaloids from Boehmeria formosana.

ABSTRACT: Boehmeria formosana, with its related species, demonstrates anti-glycemic effect, inhibition of HBV production, anti-cancer activities, etc. Some indolizidine alkaloids from the same genus are bioactive but sensitive to light. To overcome this problem and obtain more phenanthroindolizidine alkaloids, isolation was performed in darkness, yielding 10 new indolizidine alkaloids and 17 known compounds. Among them, seven enhanced glucagon-like receptor 1 (GLP-1) activity at 50 mM, especially 14 and 6 (3.5- and 2.3-fold than the negative control). This procedure yielded bioactive indolizidine alkaloids with novel structures.

SUBMITTER: Lu CY

PROVIDER: S-EPMC10962671 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

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Isolation of GLP-1 enhancing indolizidine alkaloids from Boehmeria formosana.

Lu Ching-Yi CY Huang Zheng-Ying ZY Chen Meng-Chin MC Liu Hui-Kang HK Lee Shoei-Sheng SS Chang Chia-Chuan CC

Journal of food and drug analysis 20231201 4

Boehmeria formosana, with its related species, demonstrates anti-glycemic effect, inhibition of HBV production, anti-cancer activities, etc. Some indolizidine alkaloids from the same genus are bioactive but sensitive to light. To overcome this problem and obtain more phenanthroindolizidine alkaloids, isolation was performed in darkness, yielding 10 new indolizidine alkaloids and 17 known compounds. Among them, seven enhanced glucagon-like receptor 1 (GLP-1) activity at 50 mM, especially 14 and 6 ...[more]

PMID: 38526826

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