Comparison of Large Animal Models for Acute Ischemic Stroke: Which Model to Use?

ABSTRACT: Translation of acute ischemic stroke research to the clinical setting remains limited over the last few decades with only one drug, recombinant tissue-type plasminogen activator, successfully completing the path from experimental study to clinical practice. To improve the selection of experimental treatments before testing in clinical studies, the use of large gyrencephalic animal models of acute ischemic stroke has been recommended. Currently, these models include, among others, dogs, swine, sheep, and nonhuman primates that closely emulate aspects of the human setting of brain ischemia and reperfusion. Species-specific characteristics, such as the cerebrovascular architecture or pathophysiology of thrombotic/ischemic processes, significantly influence the suitability of a model to addres

SUBMITTER: Taha A 

PROVIDER: S-EPMC10962757 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature