FDG-PET markers of heterogeneity and different risk of progression in amnestic MCI.

ABSTRACT:

Introduction

Amnestic mild cognitive impairment (aMCI) is emerging as a heterogeneous condition.

Methods

We looked at a cohort of N = 207 aMCI subjects, with baseline fluorodeoxyglucose positron emission tomography (FDG-PET), T1 magnetic resonance imaging, cerebrospinal fluid (CSF), apolipoprotein E (APOE), and neuropsychological assessment. An algorithm based on FDG-PET hypometabolism classified each subject into subtypes, then compared biomarker measures and clinical progression.

Results

Three subtypes emerged: hippocampal sparing-cortical hypometabolism, associated with younger age and the highest level of Alzheimer's disease (AD)-CSF pathology; hippocampal/cortical hypometabolism, associated with a high percentage of APOE ε3/ε4 or ε4/ε4 carriers; medial-temporal h

SUBMITTER: Caminiti SP 

PROVIDER: S-EPMC10962797 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature