Chitosan nanoparticles improve the effectivity of miltefosine against Acanthamoeba.

ABSTRACT:

Background

Acanthamoeba keratitis (AK) is a corneal sight-threatening infection caused by the free-living amoebae of the genus Acanthamoeba. Early and appropriate treatment significantly impacts visual outcomes. Mucoadhesive polymers such as chitosan are a potential strategy to prolong the residence time and bioavailability of the encapsulated drugs in the cornea. Regarding the recent administration of miltefosine (MF) for treating resistant AK, in the present study, we synthesized miltefosine-loaded chitosan nanoparticles (MF-CS-NPs) and evaluated them against Acanthamoeba.

Methodology/principal findings

Chitosan nanoparticles (CNPs) were prepared using the ionic gelation method with negatively charged tripolyphosphate (TPP). The zeta-potential (ZP) and the particle size of

SUBMITTER: Latifi A 

PROVIDER: S-EPMC10962830 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature