Genetic analysis of PALB2 gene WD40 domain in canine mammary tumour patients.

ABSTRACT:

Background

DNA repair mechanisms are essential for tumorigenesis and disruption of HR mechanism is an important predisposing factor of human breast cancers (BC). PALB2 is an important part of the HR. There are similarities between canine mammary tumours (CMT) and BCs. As its human counterpart, PALB2 mutations could be a predisposing factor of CMT.

Objectives

In this study, we aimed to investigate the impacts of PALB2 variants on tumorigenesis and canine mammary tumor (CMT) malignancy.

Methods

We performed Sanger sequencing to detect germline mutations in the WD40 domain of the canine PALB2 gene in CMT patients. We conducted in silico analysis to investigate the variants, and compared the germline PALB2 mutations in humans that cause breast cancer (BC) with the variant

SUBMITTER: Cıldır OS 

PROVIDER: S-EPMC10962921 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature