H₂S preconditioning induces long-lived perturbations in O₂ metabolism.

ABSTRACT: Hydrogen sulfide exposure in moderate doses can induce profound but reversible hypometabolism in mammals. At a cellular level, H₂S inhibits the electron transport chain (ETC), augments aerobic glycolysis, and glutamine-dependent carbon utilization via reductive carboxylation; however, the durability of these changes is unknown. We report that despite its volatility, H₂S preconditioning increases P_50(O2), the O₂ pressure for half-maximal cellular respiration, and has pleiotropic effects on oxidative metabolism that persist up to 24 to 48 h later. Notably, cyanide, another complex IV inhibitor, does not induce this type of metabolic memory. Sulfide-mediated prolonged fractional inhibition of complex IV by H₂S is modulated by sulfi

SUBMITTER: Hanna DA 

PROVIDER: S-EPMC10962982 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature