Genome-wide analysis of spina bifida risk variants in a case-control study from Bangladesh.

ABSTRACT:

Background

Human studies of genetic risk factors for neural tube defects, severe birth defects associated with long-term health consequences in surviving children, have predominantly been restricted to a subset of candidate genes in specific biological pathways including folate metabolism.

Methods

In this study, we investigated the association of genetic variants spanning the genome with risk of spina bifida (i.e., myelomeningocele and meningocele) in a subset of families enrolled from December 2016 through December 2022 in a case-control study in Bangladesh, a population often underrepresented in genetic studies. Saliva DNA samples were analyzed using the Illumina Global Screening Array. We performed genetic association analyses to compare allele frequencies between 112 cas

SUBMITTER: Tindula G 

PROVIDER: S-EPMC10963057 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature