Causal relationship between multiparameter brain MRI phenotypes and age: evidence from Mendelian randomization.

ABSTRACT: To explore the causal relationship between age and brain health (cortical atrophy, white matter integrity, white matter hyperintensities and cerebral microbleeds in various brain regions) related multiparameter imaging features using two-sample Mendelian randomization. Age was determined as chronological age of the subject. Cortical volume, white matter micro-integrity, white matter hyperintensity volume and cerebral microbleeds of each brain region were included as phenotypes for brain health. Age and imaging of brain health related genetic data were analysed to determine the causal relationship using inverse-variance weighted model, validated by heterogeneity and horizontal pleiotropy variables. Age is causally related to increased volumes of white matter hyperintensities (β = 0.1

SUBMITTER: Wang X 

PROVIDER: S-EPMC10963122 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature