Dataset Information

CXCR4-targeted Theranostics in Hematooncology: Opportunities and Challenges.

ABSTRACT: C-X-C motif chemokine receptor 4 (CXCR4) is overexpressed in a multitude of cancers, including neoplasms of hematopoietic origin. This feature can be leveraged by a theranostic approach, which provides a read-out of the actual CXCR4 expression in vivo, followed by CXCR4-targeted radioligand therapy (RLT) exerting anti-cancer as well as myeloablative efficacy. In a recent meeting of hematooncology and nuclear medicine specialists, statements on the current clinical practice and future perspectives of this innovative concept were proposed and summarized in this opinion article. Experts concluded that i) CXCR4-directed [68Ga]Ga-PentixaFor PET/CT has the potential to improve imaging for patients with marginal zone lymphoma; ii) CXCR4-targeted RLT exerts anti-lymphoma efficacy and myeloablative effects in patients with advanced, treatment-refractory T-cell lymphomas; iii) prospective trials with CXCR4-based imaging and theranostics are warranted.

SUBMITTER: Werner R

PROVIDER: S-EPMC10963126 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature

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CXCR4-targeted Theranostics in Hematooncology: Opportunities and Challenges.

Werner Rudolf R Haug Alexander A Buske Christian C Heidegger Simon S Illert Anna L AL Bassermann Florian F Herhaus Peter P Buck Andreas A Duell Johannes J Topp Max S MS Kraus Sabrina S Einsele Hermann H Lapa Constantin C Raderer Markus M Lenz Georg G Habringer Stefan S von Tresckow Bastian B Keller Ulrich U

Nuklearmedizin. Nuclear medicine 20240108 2

C-X-C motif chemokine receptor 4 (CXCR4) is overexpressed in a multitude of cancers, including neoplasms of hematopoietic origin. This feature can be leveraged by a theranostic approach, which provides a read-out of the actual CXCR4 expression in vivo, followed by CXCR4-targeted radioligand therapy (RLT) exerting anti-cancer as well as myeloablative efficacy. In a recent meeting of hematooncology and nuclear medicine specialists, statements on the current clinical practice and future perspective ...[more]

PMID: 38190998

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Dataset Information

CXCR4-targeted Theranostics in Hematooncology: Opportunities and Challenges.

Publications

CXCR4-targeted Theranostics in Hematooncology: Opportunities and Challenges.

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