Coupled Activation of the Hyperdirect and Cerebellothalamic Pathways with Zona Incerta Deep Brain Stimulation.

ABSTRACT:

Background

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or ventral intermediate nucleus (VIM) are established targets for the treatment of Parkinson's disease (PD) or essential tremor (ET), respectively. However, DBS of the zona incerta (ZI) can be effective for both disorders. VIM DBS is assumed to achieve its therapeutic effect via activation of the cerebellothalamic (CBT) pathway, whereas the activation of the hyperdirect (HD) pathway likely plays a role in the mechanisms of STN DBS. Interestingly, HD pathway axons also emit collaterals to the ZI and red nucleus (RN) and the CBT pathway courses nearby to the ZI.

Objective

The aim was to examine the ability of ZI DBS to mutually activate the HD and CBT pathways in a detailed computational model of human DB

SUBMITTER: Bingham CS 

PROVIDER: S-EPMC10963140 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature