Epigenetic modulation of long noncoding RNA H19 in oral squamous cell carcinoma-A narrative review.

ABSTRACT: Oral squamous cell carcinoma (OSCC) showed a seemingly increasing incidence in the last decade. In India, despite the use of tobacco decreased rapidly, in the past five years, the incidence pattern of OSCC over gender and age showed a drastic shift. About 51 % of the head and neck cancers are not associated with habits. Studies exploring various contributing factors in the incidence of this malignancy have documented. Recently, the epigenetic factors associated with the induction and progression of OSCC were explored. More than 90 % of the human genome is made up of non-coding transcriptome, which believed to be noises. However, these non-coding RNAs were identified to be the major epigenetic modulators, which raises concern over incidence of carcinoma in non-habit patients. H19 is a long

SUBMITTER: Rajendran P 

PROVIDER: S-EPMC10963247 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature