Tau maturation in the clinicopathological spectrum of Lewy body and Alzheimer's disease.

ABSTRACT:

Objective

Alzheimer's disease neuropathologic change and alpha-synucleinopathy commonly co-exist and contribute to the clinical heterogeneity of dementia. Here, we examined tau epitopes marking various stages of tangle maturation to test the hypotheses that tau maturation is more strongly associated with beta-amyloid compared to alpha-synuclein, and within the context of mixed pathology, mature tau is linked to Alzheimer's disease clinical phenotype and negatively associated with Lewy body dementia.

Methods

We used digital histology to measure percent area-occupied by pathology in cortical regions among individuals with pure Alzheimer's disease neuropathologic change, pure alpha-synucleinopathy, and a co-pathology group with both Alzheimer's and alpha-synuclein pathologic di

SUBMITTER: Arezoumandan S 

PROVIDER: S-EPMC10963284 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature